Differences between active immunoinflammatory and postinfectious fibromyalgia (FM)

Brain perfusion in fibromyalgia patients and its differences between responders and poor responders to gabapentin

INTRODUCTION The aim of the present study was to determine the brain areas associated with fibromyalgia, and whether pretreatment regional cerebral blood flow (rCBF) can predict response to gabapentin treatment. METHODS A total of 29 women with fibromyalgia and 10 healthy women (without pain) matched for age were finally enrolled in the study. Technetium-99m ethyl cysteinate dimer single phot...

Conformational Differences between Active Angiotensins and Their Inactive Precursors

The peptide conformation in the context of a protein polypeptide chain is influenced by proximal amino acid residues. However, the mechanisms of this interference remain poorly understood. We studied the conformation of angiotensins 1, 2 and 3, which are produced naturally in a sequential fashion from a precursor protein angiotensinogen and contain an identical peptide core structure. Using the...

Differences between Active and Passive Failure in Whole Skeletal Muscle

Extensive research has been performed examining eccentric contraction and related muscle injury. Only a few studies have examined muscle failure due to an imposed tissue strain. Those that have examined failure tend to investigate active muscle failure and define failure as complete tearing of the muscle. However, muscle damage is known to occur well before a tear is apparent, and failure may b...

Virus-Induced Immunoinflammatory Lesions

Differences in unpleasantness induced by experimental pressure pain between patients with fibromyalgia and healthy controls.

Pain possesses both sensory and affective dimensions, which are highly correlated yet distinct. Comparison of these dimensions within experimental pain settings has resulted in the construct of relative unpleasantness. Relative unpleasantness is defined as the amount of affective unpleasantness elicited for a given sensory magnitude. The aim of this study was to determine the relationship betwe...